Findings from a novel study in Biological Psychiatry highlight the layered and complex underpinnings of depression, revealing that multiple brain profiles may manifest as the same clinical symptoms (IMAGE)
Caption
This image depicts theoretical perspectives on the relationship between clinical and neurobiological heterogeneity in the depression population. (A). In the one-to-one theory, each clinical feature is expected to have a one-to-one association with a neurobiological explanation. (B). In the many-to-one theory, multiple distinct neurobiological mechanisms can give rise to the same clinical presentation. Note that the one-to-one and many-to-one theories are not mutually exclusive and many-to-one mapping may be observed in some clinically dissociated groups, but not others. Heterogeneity may either take the form of well-separated clusters (C) or may vary along more continuous dimensions (D).
Credit
Biological Psychiatry / Hannon et al.
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