Tumor Growth (IMAGE)
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The discovery shows that the production of ribosomal RNA (rRNA) is connected to how cells manage RNA splicing (a process that edits RNA). In studies of cancer cell lines using drugs that block rRNA production, a new stress response pathway was revealed. This pathway involves proteins called RPL22, RPL22L1, and MDM4. RPL22 plays a key role in controlling RNA splicing in coordination with rRNA production.
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Courtesy of Cell Chemical Biology
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