Model of ELAV-mediated circRNA biogenesis (IMAGE)
Caption
The ELAV protein binds to specific regions of the precursor RNA, namely to so-called reverse complementary sequences (RCMs) in the introns flanking the "backsplice junction" (BSJ) that is crucial for circRNA formation. This binding enables the formation of an RNA secondary structure that brings the splice sites for backsplicing into close spatial proximity. The entire mechanism specifically promotes the formation of a circular RNA at the backsplice junction (BSJ), while simultaneously suppressing conventional linear splicing at the same genomic locus.
Credit
MPI of Immunobiology & Epigenetics, Hilgers
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CC BY-ND