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Sanford Burnham Prebys

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The scientists demonstrated an absence of Ashwell-Morell receptor ligands on glycoforms of intestinal alkaline phosphatase (IAP) featuring glycan chains with two antennae, known as biantennary. They found, however, that when IAP dimerizes, two biantennary sugar chain structures are brought into close proximity, thereby mimicking multi-valent tri- and tetra-antennary glycan structures required for Ashwell Morell receptor binding.

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Jamey Marth and Sanford Burnham Prebys

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