In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control (IMAGE)
Caption
Figure 4. In vivo imaging of U-87 MG xenograft model with varying mass doses of 89Zr-labeled KLG-3 or isotype control. (A) Representative maximum-intensity projection (MIP) and axial PET/CT images at 144 h after injection. (B) Tumoral uptake ([%ID/g]max). (C) Blood clearance ([%ID/g]mean). (D) TNR of 5, 10, and 30 µg at 144 h after injection. (E) Comparison of tumoral uptake ([%ID/g]max) at 144 h after injection of all masses (5, 10, 20, and 30 µg) of 89Zr-labeled KLG-3. *P < 0.05, **P < 0.01, ***P < 0.001; P values shown from ANOVA. IgG = immunoglobulin G; ns = not significant; TNR-B = blood TNR; TNR-K = kidney TNR; TNR-M = muscle TNR.
Credit
Image created by L Gajecki et al., Memorial Sloan Kettering Cancer Center, New York, NY; Sander Tri-Institutional Therapeutics Discovery Institute, New York, NY; The University of Texas MD Anderson Cancer Center, Houston, TX.
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