Basal ganglia circuitry in Tourette syndrome (TS) (IMAGE)
Caption
A) Outline of basal ganglia anatomy in a coronal human brain section. B) UMAP clustering of nuclei from 12 brains based on snRNA-seq data. C) Wiring diagram of basal ganglia circuitry. D) Normalized difference in cell type proportions comparing TS to control brains assessed using snRNA-seq data. **p-value < 0.001 by paired t-test. At the bottom, biological annotation of differentially expressed genes between TS and control brains in the indicated cell groups.
Credit
Biological Psychiatry / Wang et al.
Usage Restrictions
Please include attribution.
License
Original content