Proposed mechanism of Hdy7-induced lysosomal biogenesis and autophagy. (IMAGE)

Science China Press

Proposed mechanism of Hdy7-induced lysosomal biogenesis and autophagy.

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Hdy-7 directly binds to TrxR1/2, triggering ROS accumulation and p53 activation. Activated p53 negatively regulates mTORC1 signaling, which is one of the major kinases responsible for the phosphorylation of TFEB and TFE3. The autophagy-lysosomal pathway is activated via the TrxR-p53-TFEB/TFE3 axis by Hdy-7, leading to enhanced lysosomal biogenesis and excessive autophagy, which facilitates further cell death.

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