Proposed model showing adipocytes underling ERS secrete ASM to generate ceramide which is transported via HDL. (IMAGE)

Chinese Academy of Sciences Headquarters

Proposed model showing adipocytes underling ERS secrete ASM to generate ceramide which is transported via HDL.

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Proposed model showing adipocytes underling ERS secrete ASM to generate ceramide which is transported via HDL. This process reduces membrane fluidity, impairs SERCA activity, disrupts calcium homeostasis, and thereby activates the UPR.

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HUO Yazhen

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