Mc-mitochondria exhibit superior performance for in vivo mitotherapy. (IMAGE)
Caption
Mc-mitochondria exhibit superior performance for in vivo mitotherapy. a Schematic illustration of the establishment of the mouse OA model and the experimental design to evaluate the value of mitochondrial amplification for in vivo applications. b Safranin-O/Fast green staining of joint sections at 12 weeks. Scale bar, 50 μm. c Modified and maximum OARSI scoring system (sample = 6 for each group). d Immunohistochemical staining (COL2, ACAN) of joint sections at 12 weeks. Scale bar, 50 μm. e Quantification of COL2 and ACAN in cartilage tissues at 12 weeks (sample = 6 for each group). All data are presented as mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001. P values were determined using one-way ANOVA (c, e). OARSI Osteoarthritis Research Society International.
Credit
Bone Research
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