PET protein atlases for various [11C]MC1 positron PET imaging metrics targeting COX-2. (IMAGE)
Caption
Figure 7. PET protein atlases for various [11C]MC1 positron PET imaging metrics targeting COX-2. (A and B) Distribution volume (VT) (A) and binding potential (BPND) (B) through volume-based analysis (left) and surface-based analysis (right) tailored to respect cortical geometry of the brain to enhance precision. (C) Between-subject variability for total COX-2 uptake, quantified as coefficient of variation, contrasting volumetric analysis (left) and surface-based analysis (right). Surface-based analysis respects the unique cortical geometry of individual participants (left), thereby reducing partial-volume effects. Moreover, a surface-based approach mitigates increased between-subject variability observed using volumetric analysis, which is exacerbated by differences in anatomy that lead to edge or boundary effects. By respecting cortical geometry, surface-based analysis reduces between-subject variability in the cortex, consequently lowering the number of participants needed in group analyses to detect similar statistical significance.
Credit
Original image generated for this paper by Martin Noergaard, 1Intramural Research Program, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA; 2Department of Computer Science, University of Copenhagen, 1165 Copenhagen, Denmark. Edited by Robert B. Innis and Xuefeng Yan, Intramural Research Program, National Institute of Mental Health, 10 Center Drive, Bethesda, MD 20892, USA.
Usage Restrictions
Please give appropriate credit.
License
Original content