Cascade functioning of the coordination nanomedicine and its mediated anti-tumor mechanisms (IMAGE)
Caption
The constructed coordination nanomedicine can specifically capture Fe3+, leading to the breakage of partial Zn-O bonds and the formation of hexacoordinated Fe-DHT structure, enabling the environmental Fe depletion and the release of Zn2+. Then, the highly reductive Fe centers in the Fe-DHT structure can promote the catalytic ROS (O2•- and •OH) production under the acidic condition. Based on these, this nanomedicine can chelate tumor extracellular and intracellular Fe ions and accumulate in the lysosomes, resulting in the Fe depletion, ROS generation, and Zn2+ release, which not only inhibits the EMT and CSC stemness, but also causes tumor cell oxidative damage, resultantly activating both apoptosis and ferroptosis of tumor cells. Finally, the nanomedicine can suppress the tumor growth, recurrence and metastasis in vivo.
Credit
©Science China Press
Usage Restrictions
Use with credit.
License
Original content