The structure of Huntington's fibrils (IMAGE)
Caption
Visualization of the protein clumps associated with Huntington’s disease, determined by combining simulations and multiple complementary types of experiments. The figure shows the overall structure at the top, with aspects of the disordered surface (fuzzy coat, left) and the protected core (right) shown in detail below. This coat is targeted by other proteins in the cell. However, the findings in the study suggest that the fuzzy coat will resist these interactions, which has implications for our understanding of how these toxic proteins can be targeted for destruction.
Credit
Adapted from Bagherpoor Helabad, M. et al, Nature Communications.
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License
CC BY-SA