IL-8+ neutrophils induce a vicious cycle that drives unstoppable inflammation in AH. (IMAGE)
Caption
Peripheral neutrophils from sAH patients initially express low levels of IL-8. However, on infiltrating the sAH liver, these neutrophils are stimulated by the inflammatory environment, including mediators such as TNF-α and IL-1β, to produce high levels of IL-8. This IL-8 production amplifies systemic IL-8 levels, further recruiting neutrophils to the liver and perpetuating a vicious cycle of inflammation. As central drivers of this inflammatory loop, IL-8+ neutrophils represent promising therapeutic targets for managing sAH. Diagram was created with BioRender.com. AH, alcohol-associated hepatitis; IL, interleukin; sAH, severe AH; TNF, tumour necrosis factor.
Credit
By Yukun Guan, Dechun Feng, Luca Maccioni, Yang Wang, Bin Gao.
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CC BY-NC