Circadian nutrition regulates the brain-muscle axis to reduce fatigue (IMAGE)

Science China Press

Circadian nutrition regulates the brain-muscle axis to reduce fatigue

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Night restricted feeding (NRF), akin to 16:8 intermittent fasting in humans, increases muscle endurance and cognitive performance in obesogenic diet-fed mice. Day restricted feeding (DRF), akin to Ramadan fasting in humans, increases muscular endurance in lean mice throughout the day/night cycle. Mechanistically, the muscle clock regulates the diurnal activities of PPAR and Perilipin-5, which are required for muscle metabolism and contraction. TRF, time-restricted feeding; SCN, suprachiasmatic nucleus.

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