Overview of the proposed hybrid in silico/in-cell controller (HISICC). (IMAGE)

Fujita Health University

Overview of the proposed hybrid in silico/in-cell controller (HISICC).

Caption

The diagram depicts how a negative feedback loop engineered directly into the bacteria can help regulate the production of a key enzyme. The in-cell feedback controller enables HISICC to apply brakes based on enzyme concentration, thereby reducing fatty acid yield losses from PMM-related enzyme expression issues.

Credit

Katsuyuki Kunida from Fujita Health University, Japan

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