Tensor-based morphometry (TBM) analysis of T1-weighted MRI scans shows a comparison of brain volumes in participants with opioid use disorder (OUD) and healthy control participants. (IMAGE)
Caption
Tensor-based morphometry (TBM) analysis of T1-weighted MRI scans shows a comparison of brain volumes in participants with opioid use disorder (OUD) and healthy control participants. Widespread volume differences are observed between participants with OUD and healthy controls when accounting for total brain volume. Specifically, the bilateral thalamus, right caudate and orbitofrontal cortex, and right medial temporal lobe show lower volume in participants with OUD compared with healthy controls. The left medial temporal lobe, brainstem, bilateral cerebellum, left insula, and right dorsal posterior cingulate cortex show greater volume in those with OUD compared with healthy controls. All results are shown at P < .05, corrected for multiple comparisons. The color scale indicates the z statistic, whereby blue to pink represents smaller volumes in the OUD group compared with healthy controls, and red to yellow represents larger volumes in the OUD group compared with healthy controls. L = left, R = right.
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Radiological Society of North America (RSNA)
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