Visualizing RNA Assembly: From Cryo-Electron Tomography to 3D Structure (IMAGE)

Aarhus University

Visualizing RNA Assembly: From Cryo-Electron Tomography to 3D Structure

Caption

Left side of figure shows the process of individual-particle cryo-electron tomography (IPET) where RNA samples are frozen on a grid, then imaged by tilting the sample at different angles. The images are then used to reconstruct the 3D shape of the particle. Right side of figure shows the 3D shape of individual RNA molecules.

Credit

Liu, J., McRae, E.K.S., Zhang, M. et al. Non-averaged single-molecule tertiary structures reveal RNA self-folding through individual-particle cryo-electron tomography. Nat Commun 15, 9084 (2024). https://doi.org/10.1038/s41467-024-52914-1

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