Relationship between the expressions of DLL3, ASC1, TTF-1 and Ki-67: First steps of precision medicine at SCLC (IMAGE)
Caption
Figure 1: Representative slides of 3 different cases of SCLC (A–C), showing distinct morphology (top panel, HE sections) and expressions of DLL3 in the second row, TTF1 in the third row, ASCL1 expression in the fourth row and ki67 index in the fifth and final row. The first cases (1st column) shows a moderate expression of DLL3, strong positivity for TTF1, weak and focal positivity for ASCL1; the second case (second column) shows negative DLL3, negative TTF1, strong and diffuse nuclear expression for ASCL1, while the third case (3rd column) shows strong positivity for DLL3, TTF1 and ASCL1. All cases show a high ki-67 proliferative index. Bars = 50 µM (micrometers).
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2024 Silva et al.
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