Alzheimer’s and alcohol use disorder share similar gene expression patterns (IMAGE)

Scripps Research Institute

Alzheimer’s and alcohol use disorder share similar gene expression patterns

Caption

Researchers characterized the gene expression of more than 100,000 individual cells from brains of humans with Alzheimer’s disease and compared the patterns to those in individuals with alcohol use disorder (AUD). Compared to healthy individuals, they showed that there was significant overlap in gene expression changes for those with Alzheimer’s and AUD. Pathways that were downregulated in AUD and at least one AD stage are shown in purple, and pathways that are upregulated in AUD and at least one AD stage are shown in pink.

Credit

Arpita Joshi and Pietro P. Sanna (Scripps Research)

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