Colorectal Cancer Liver Metastasis (IMAGE)
Caption
Multiplex immunofluorescence of a patient’s colorectal cancer liver metastasis showing the diversity of cell states from normal intestinal states (dark blue) to highly plastic injury repair (cyan) and fetal-like (yellow) states — enabling transformation (lineage plasticity) into non-intestinal cell states: skin-like cells (red) and neuroendocrine cells (orange).
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Elizabeth Benitez, Memorial Sloan Kettering Cancer Center
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