Self-glycan binding to N-acetylglucosaminyltransferase-IVa (GnT-IVa) and GnT-IVb reduces enzyme activity (IMAGE)

Institute for Glyco-core Research (iGCORE), Tokai National Higher Education and Research System

Self-glycan binding to N-acetylglucosaminyltransferase-IVa (GnT-IVa) and GnT-IVb reduces enzyme activity

Caption

Specific glycans attached to the GnT-IVa and GnT-IVb can bind to the enzyme’s ligand-binding site, interfering with recognition and binding to the glycosylation proteins’ normal glycoprotein substrates.

Credit

YASUHIKO KIZUKA, GIFU UNIVERSITY

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