Proposed model for the persistent activation of DDR signaling and P53-AEN axis in the liver after transitioning from a WD to a CD even when MASLD is histologically resolved (IMAGE)
Caption
WD, western diet; CD, chow diet; DDR, DNA damage response; AEN, apoptosis-enhancing nuclease; MASLD, Metabolic dysfunction–associated steatotic liver disease.
Credit
Jian-Gao Fan, Cen Xie, Zi-Yuan Zou, Tian-Yi Ren
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Credit must be given to the creator. Only noncommercial uses of the work are permitted.
License
CC BY-NC