Three-dimensional structures of two target proteins (IMAGE)

University of Bonn

Three-dimensional structures of two target proteins

Caption

Three-dimensional structures of two target proteins, histone deacetylase 6 (blue) and tyrosine-protein kinase JAK2 (red), together with a selective inhibitor of each enzyme. The dual inhibitor in the center is active against both targets. The prediction of compounds with predefined dual-target activity is the task of the chemical language model.

Credit

Figure: Sanjana Srinivasan & Jürgen Bajorath

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