Signal transduction by GRB2 and SOS1. (IMAGE) Tokyo Metropolitan University Caption Signal transduction by GRB2 and SOS1. When some substances bind to a membrane receptor, a reaction occurs between the receptor and GRB2, which then goes on to bind and activate SOS1. SOS1 can then react with RAS, a key step in the biomolecular cascade leading to DNA transcription inside the nucleus. Credit Tokyo Metropolitan University Usage Restrictions Please give credit for use. License Original content Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.