LINE-1 elements control gene expression in early human development (IMAGE)
Caption
The images show the inside of the cell nucleus at an 8-cell stage (left) and at a later stage (right). Chromosome 19 is shown in red whereas the nucleolus containing the gene-silencing machinery is in green. One can see close intermingling of chromosome 19 and the gene-silencing machinery at the later developmental stage (right). Inhibition of LINE-1 reverses the cells to the earlier 8C state, which has less green/red overlap (left).
Credit
Dr. Juan Zhang and Dr. Miguel Ramalho-Santos
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