Gianpietro Dotti, MD (IMAGE)
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“CAR-T cells are very potent cells. However, the most surprising finding in our work is that these potent cells are strongly inhibited in tumor models that recapitulate the complexity of the tumor microenvironment,” said UNC Lineberger's Gianpietro Dotti, MD, the paper’s corresponding author. “In particular, tumor-associated macrophages seem to have a potent inhibitory effect on CAR-T cells. CAR-NKT seem capable to avoid the inhibitory effects of macrophages since they can directly target them.”
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UNC Lineberger Comprehensive Cancer Center
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