Schematic illustration of the UCNPs/CuₓOS@ZIF nanoprboes and their applications in H₂S biosensing (IMAGE)

Light Publishing Center, Changchun Institute of Optics, Fine Mechanics And Physics, CAS

Schematic illustration of the UCNPs/CuₓOS@ZIF nanoprboes and their applications in H₂S biosensing

Caption

Schematic illustration of the UCNPs/CuxOS@ZIF nanoprboes and their applications in H2S biosensing. The designed UCNPs is encapsulated in ZIF-8 along with CuxOS nanoparticles. Due to the quenching of UCL by CuxOS, the UCL signal of UCNPs/CuxOS@ZIF nanocomposite probe under 980 nm excitation is weak. At this time, the probe showed a significant CD signal due to CuxOS. When H2S exists in the detection environment, the destruction of CuxOS by H2S weakens the CD signal of the probe, while the UCL signal of UCNPs is restored. Based on this principle, UCL/CD dual-mode sensing against H2S is realized in vitro. At the same time, as one of the typical biomarkers of cancer, the high expression of H2S in the tumor also enhances the UCL signal of the probe inside the tumor, achieving bioimaging in vivo.

Credit

by Yang Lu, Xu Zhao, Dongmei Yan, Yingqian Mi, Peng Sun, Xu Yan, Geyu Lu, and Xiaomin Liu.

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.