(IMAGE)
Caption
Figure 4. Structural effects of a single frameshift homozygous nucleotide deletion in the SPAG9/JIP4 gene. Representation of the three-dimensional model in tapes. (A) Region of the SPAG9wt protein after position 914 (in yellow and orange). (B) SPAG9wt and SPAG9Tyr914Ter (violet) proteins. There was no alignment of the structures. The effect of the charges of the amino acids was lost, affecting their folding and inducing changes in angles that alter the functional interaction.
Credit
Natalia Acosta-Baena
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