(IMAGE)

Tokyo Medical and Dental University

Caption

Researchers investigated the function of PQBP3, a protein that was previously linked to certain neurodegenerative diseases, and unveiled its role in maintaining the integrity of the nuclear membrane. In senescent (aged) cells, PQBP3 concentration is decreased thereby promoting Lamin B1 degradation, and PQBP3 leaks from its typical place in the nucleolus to the cytosol, which in turn causes the nuclear membrane to get destabilized. 

Credit

Department of Neuropathology, TMDU

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