A proposed model of how StFC-II was manipulated by RxLR effector Pi22922 to suppress host imunitiy. (IMAGE)

Nanjing Agricultural University The Academy of Science

A proposed model of how StFC-II was manipulated by RxLR effector Pi22922 to suppress host imunitiy.

Caption

A proposed model of how StFC-II was manipulated by RxLR effector Pi22922 to suppress host imunitiy. Phytophthora infestans RxLR effector Pi22922 was secreted from haustoria and translocated in the nucleus and cytoplasm. In cytoplasm, Pi22922 targeted the chloroplast protein StFC-II and inhibited its degradation mediated by E3 ubiquitin ligase CHIP, thereby promoting its accumulation in chloroplasts. Much StFC-II accumulation in the chloroplast disrupts the subtle balance of chlorophyll and heme biosynthesis, which leads to decreased cROS and cytoplasm ROS production and inhibition of the defense-related genes’ expression. Pi22922 may also target host nuclear-located proteins to simultaneously suppress immunity.

Credit

Horticulture Research

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