Expression products and effects of rare mutated genes in CRC. (IMAGE)

China Anti-Cancer Association

Expression products and effects of rare mutated genes in CRC.

Caption

Expression products and effects of rare mutated genes in CRC. (A) ERBB2 (HER2), (B) ALK, (C) ROS1, (D) NTRK1, NTRK2, and NTRK3, (E) RET, (F) EGFR, and (G) FGFR2 activate Ras-Raf-MAPK, PI3K-AKT, and PIP2-IP3 signaling pathways and ultimately facilitate cell migration, cell proliferation, gene expression, and drug resistance.

Credit

Cancer Biology & Medicine

Usage Restrictions

Credit must be given to the creator.

License

CC BY

Disclaimer: AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert system.