Therapeutic potential of Wif1oe-OB-derived EVs in osteoporosis through regulation of osteogenic differentiation and mitophagy. (IMAGE)

Science China Press

Therapeutic potential of Wif1oe-OB-derived EVs in osteoporosis through regulation of osteogenic differentiation and mitophagy.

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Wif1 overexpression accelerated osteogenic differentiation by activating genes related to late-stage osteogenic differentiation and mitophagy processes. Moreover administering Wif1-overexpressing OB-derived EVs to OVX mice partially reversed bone loss and countered the suppression of osteogenic differentiation in BMSCs.

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