Mb reaction with benzyl diazoketone. (IMAGE)

Stevens Institute of Technology

Mb reaction with benzyl diazoketone.

Caption

a Mb(H64G,V68A)-catalyzed cyclopropanation of styrene with benzyl diazoketone (BDK) and substrate scope of the biocatalyst (box; R = aryl or alkyl; R’ = H or Me). b Color change of a Mb(H64G,V68A) solution upon addition of BDK (box) and corresponding transition in the UV-Vis absorption spectrum (2 mM Mb(H64G,V68A)) in 50 mM sodium borate buffer (NaBB) (pH 9.0), anaerobic conditions, before (red curve) and after (green curve) addition of BDK.

Credit

Nam, D., Bacik, JP., Khade, R.L. et al. Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone. Nat Commun 14, 7985 (2023). https://doi.org/10.1038/s41467-023-43559-7

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