Researchers in Purdue University’s College of Pharmacy have developed and validated a novel series of small-molecule inhibitors that promote antitumor immunity and hold promise as novel anticancer agents.

The powerful new autism-research tool sorts out which health effects come from genes and which come from a child's environment.

Doctors and scientists from the University of Wisconsin–Madison and the Morgridge Institute for Research used several methods to better characterize the disease severity of people suffering from HFpEF, a form of heart failure that affects more than 3 million Americans and is severely debilitating. Using advanced invasive and noninvasive cardiac tests, they determined that right ventricle dysfunction is the most important determinant for prognosis and learned more about how problems in the left heart contribute to right heart and pulmonary issues.. With long-read RNA sequencing of biopsied myocardial tissue, they also identified variants of genes expressed in those with the most severe cases that impact mitochondrial function and RNA metabolism. This lays the foundation for clinical trials for this hard-to-treat and often fatal form of heart failure within the next few years.