MIT researchers designed nanoparticles that can deliver an immune-stimulating molecule called IL-12 directly to ovarian tumors. When given to mice along with checkpoint inhibitors, the treatment eliminated metastatic tumors more than 80 percent of the time.

Rates of leg and foot amputations in Illinois hospitals increased 65% between 2016 and 2023, reports a new Northwestern Medicine study. 

Men, Black patients, and those living in areas with low socioeconomic status were disproportionally affected, the study found. The dramatic spike is largely attributed to a growing prevalence of diabetes and peripheral artery disease (PAD), two chronic conditions that often lead to lower extremity amputation, the study authors said.