New research offers avenue to explore relationship between Alzheimer’s, HIV
Peer-Reviewed Publication
Updates every hour. Last Updated: 24-Oct-2026 19:16 ET (24-Oct-2026 23:16 GMT/UTC)
UNMC researchers have published an article in “Alzheimer’s & Dementia: The Journal of the Alzheimer’s Association” detailing the creation of an animal model that helps resolve questions about the relationship between HIV and Alzheimer’s disease (AD).
The work can serve as a guide for the development of novel therapeutics to halt memory loss antiretroviral drugs have shown strong potential to prevent and slow progression of both HIV and AD. Specific classes of HIV medications suppress brain inflammation and genetic mutations linked to Alzheimer’s pathology.
Mutations are changes in the molecular “letters” that make up DNA, the genetic blueprint for cells. Mutations build up with age in every cell when DNA is damaged or when cells make mistakes in fixing or copying it. Most mutations are harmless, but when they disrupt genes, they can cause cancer and other diseases.