How a single viral protein hijacks immune cells to supercharge COVID-19 infection
Peer-Reviewed Publication
Updates every hour. Last Updated: 23-Oct-2026 08:17 ET (23-Oct-2026 12:17 GMT/UTC)
Researchers at Gladstone Institutes and UC San Francisco (UCSF) have discovered how a SARS-CoV-2 protein called ORF8 is responsible for hijacking the immune system’s macrophages and causing this dangerous cycle. The work, published in Science Advances, also shows that blocking ORF8 reduces lung inflammation and damage in mice infected with SARS-CoV-2.