Designing proteins with their environment in mind
Peer-Reviewed Publication
Updates every hour. Last Updated: 12-Jul-2025 17:10 ET (12-Jul-2025 21:10 GMT/UTC)
EPFL researchers have developed a computational method to explicitly consider the impact of water while designing membrane receptors with enhanced stability and signaling, paving the way for novel drug discovery and protein engineering.
There’s a downside to being a powerful alpha male -- at least if you’re a baboon. Studies show that despite their high rank, the No. 1 males in baboon society are also some of the most stressed out, as measured by their high levels of glucocorticoid hormones. But new research reveals it’s not the time they spend fighting with other males that raises their stress. Instead, it’s the effort they put into their mates.
Specific protein receptors in the brain play a vital role in how neurons slow down or stop firing, making them targets for many disorders. Researchers have now constructed a detailed structural map of these receptors in the human brain, revealing how they assemble and how drugs bind to them.