Study sheds light on how early pancreas lesions become cancerous
Peer-Reviewed Publication
Updates every hour. Last Updated: 25-Oct-2026 21:17 ET (26-Oct-2026 01:17 GMT/UTC)
A refined precision-cut liver slice (PCLS) platform enables stable long-term culture of human liver tissues for up to 14 days while preserving multicellular architecture and disease-relevant remodeling. Using optimized slicing, oxygen delivery, and viability monitoring strategies, the study demonstrates dynamic fibrogenesis, hepatocyte dedifferentiation, regeneration, and ductular reaction in human liver explants. This extended ex vivo system provides a physiologically relevant platform for mechanistic studies, therapeutic testing, and the development of new approach methodologies (NAMs) in liver research.