Middle-aged Americans demonstrated some of the highest levels of loneliness in a new study assessing tens of thousands of 50-to-90-year-olds across 29 countries.

Treatments for seizures remain limited, in part due to incomplete understanding of the brain mechanisms involved. Now, research in fruit flies has uncovered a role for two specific brain proteins that are necessary during brain development to prevent seizures.

A new study suggests that risk factors and biomarkers related to Alzheimer’s disease are associated with cognition much earlier in life than previously recognized. The study highlights significant associations between cognition and Alzheimer’s disease risk factors as young as ages 24 to 44 and underscores the importance of early prevention. This is the first study to systematically examine Alzheimer’s disease risk factors, including biomarkers related to cognitive impairment in a large group of generally healthy middle-aged individuals in the U.S.