A large multicenter study of 17,415 Chinese participants showed that mosaic chromosomal alterations (mCAs) detected in blood were associated with colorectal cancer risk and further distinguished risk across groups defined by polygenic risk and lifestyle factors. The findings suggest that mCAs may provide complementary information for colorectal cancer risk assessment.

Researchers report in Science Bulletin that that lncCtxnd1 encodes a 59-amino-acid micropeptide, CTXND1, that suppresses hepatocellular carcinoma in experimental models by regulating tumor-associated macrophages. CTXND1 inhibits mTORC1 signaling in macrophages, limiting M2-like polarization and tumor-promoting activity. Restoring CTXND1 expression reduces tumor growth, revealing a previously unrecognized link between lncRNA-encoded micropeptides, macrophage function, and liver cancer progression.

By tuning molecular rigidity and intermolecular interactions through the incorporation of spiro units, Lu and Chen at the Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, demonstrate through systematic photophysical and device characterizations that the multi-spiro strategy effectively suppresses aggregation-caused quenching and bimolecular exciton annihilation. Consequently, the emitters exhibit outstanding resistance to concentration quenching, enabling high photoluminescence quantum yields and device efficiencies to be maintained even at high doping concentrations.

Hard carbon (HC) represents the most industrially promising anode material for sodium‑ion batteries. However, the intrinsic correlation between its nanopore architecture and sodium-ion storage kinetics as well as cycling stability remains to be clarified. In this study, lignin‑derivatives and phenolic resin were adopted as precursors. By regulating the molecular aggregation and chemical composition of the lignin precursors, HC materials with different nanoporous structures were prepared. The hard carbon anode with small carbon microcrystal size, high content of sp³ hybrid carbon and relatively large pore size is prone to structural damage during large current cycle. The disorder degree of graphene layers increases and the pore volume decreases. The destruction of the graphene layer structure not only leads to a rapid decline of plateau capacity but also reduces the formation potential of sodium clusters and increases the safety risk of sodium dendrite precipitation. This work reveals the relationship between the structure of HC nanochannels, sodium-ion storage kinetics, and cycling stability, providing a theoretical basis for the design of hard carbon anodes for fast-charging, low-temperature, long-life, and high-safety sodium-ion batteries.

This narrative review synthesizes current understanding of urban water ecological resilience and identifies three complementary enhancement pathways—technological, ecological, and governance—that are most effective when coordinated as an integrated social–ecological–technological transition. Led by Hua Zheng from the Chinese Academy of Sciences, the study highlights a persistent "definition-to-decision gap" in which resilience concepts outpace measurable indicators and operational planning tools, calling for validated metrics, sustained monitoring, and adaptive governance to transform urban water management.

Researchers at Wuhan University have developed an instrument that uses nighttime airglow to measure winds and temperatures near 87, 97, and 250 kilometers above Earth. A short field campaign in Chongyang, China, showed reasonable agreement with meteor-radar winds at the lower two heights, providing an initial assessment of the system for future studies of upper-atmospheric dynamics.

In the paper published on Science of Traditional Chinese Medicine(STCM), the authors established a progressive strategy for Alzheimer’s disease (AD) drug discovery by integrating AD cell line construction, monomer evaluation, and effective component group-based screening. They constructed an AD12 cell line stably expressing APP695/PS1-ΔE9 and characterized LPS-induced neuroinflammation using metabolomics. Screening of TCM-derived alkaloids and molecular docking showed that benzoylaconitine (BAC) bound strongly to APP and PS1. Targeted metabolomics indicated that BAC exerted anti-inflammatory effects, modulated cholinergic signaling and energy metabolism, and reduced Aβ₁₋₄₂ and IL-6 levels. In 5xFAD mice, aconite extract alleviated AD-related symptoms. This AD12 model and LPS-induced screening system may accelerate anti-AD drug discovery and support TCM modernization.

A research team at the Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, has used scanning nitrogen-vacancy microscopy and vector magnetic field reconstruction to demonstrate at the nanoscale that zigzag graphene nanoribbons embedded in hexagonal boron nitride exhibit strong perpendicular magnetic anisotropy. The work was published in the Journal of Functional Materials and Devices.

In a paper published in Earth and Planetary Physics,a research team of seismologists explores strong earthquake hazards along major active faults on the western Ordos margin using multiple seismological methods. The sparse earthquake segments overlapping low b-value anomalies mark stress-loaded locked fault patches, interpreted as potential seismogenic asperities. Theoretical magnitudes estimated from the spatial extents of these sparse segments along the faults are broadly consistent with the magnitude range of historical strong earthquakes.

A Chinese research team has shown that a self-developed, transportable cold atom gravimeter can measure the strength of Earth's gravity as accurately as the world's mainstream laser-interferometer instruments. During a two-month comparison organized by China's Crustal Movement Observation Network (CMONOC) in Wuhan, the atom-based instrument, WAG-H5-2#2508, was tested side by side with eight conventional absolute gravimeters. Its result differed from the group consensus value by only 1.4 microGal, about one billionth of the surface gravity, confirming that mechanically wear-free atom interferometry is now ready for high-precision, long-term gravity monitoring.