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19-Jun-2001
Rapid genetic disease screening possible using laser mass spectrometry
DOE/Oak Ridge National Laboratory
Laser desorption mass spectrometry is emerging as a new tool for
screening populations for various genetic diseases
19-Jun-2001
Microbe probe
DOE/Oak Ridge National Laboratory
ORNL researchers are using gene chips, mass spectrometry, and computational analysis to
understand what microbe genes do.
19-Jun-2001
Protein identification by mass spectrometry
DOE/Oak Ridge National Laboratory
ORNL researchers are improving mass spectrometry tools to speed up protein identification
and to screen for disease-causing proteins and bacteria.
19-Jun-2001
The mouse house: From old to new
DOE/Oak Ridge National Laboratory
While some ORNL mice are allowed to grow old for studies of aging, mutant mouse embryos
are being frozen, awaiting birth after the new Mouse House is built.
19-Jun-2001
SNS and biological research
DOE/Oak Ridge National Laboratory
Three world-class biological instruments are being designed for the Spallation Neutron
Source. They will help biologists determine the atomic-level structure of proteins and other
signaling compounds that allow cells to communicate and coordinate activities across an
organism. The research could lead to safer, more effective drugs.
19-Jun-2001
Lab on a chip used for protein studies
DOE/Oak Ridge National Laboratory
ORNL's lab on a chip is being used commercially to identify proteins and shows promise for
drug discovery and disease screening.
18-Jun-2001
Genes and proteins
DOE/Oak Ridge National Laboratory
Consider a living cell, the fundamental unit of life. Each human cell contains the entire
human genome—some 35,000 genes. But only some genes are expressed within a
specific cell, resulting in the production of specific proteins. The genes that turn on in a
liver cell, for example, are different from the genes that are expressed in a brain cell.
18-Jun-2001
Searching for mouse models of human
DOE/Oak Ridge National Laboratory
Mutant mice are tested by ORNL researchers and their collaborators to determine if these
mice have diseases similar to those that afflict humans. Therapies tried on mouse models
could lead to new medical treatments.
18-Jun-2001
Gene chip engineers
DOE/Oak Ridge National Laboratory
At ORNL, microarrays are being made faster and cheaper to study gene expression in cells
from mice, fish, and other organisms.