Researchers using the Oak Ridge Leadership Computing Facility's can foresee substantial changes in scientific application code development. The OLCF's new supercomputer, Titan, will use a hybrid architecture of conventional, multipurpose CPUs and high-performance GPUs. The machine will supplant the OLCF's current fastest supercomputer, Jaguar, a Cray XT5 using an entirely CPU-based platform. Members of the OLCF's Application Performance Tools group understand the challenge. Their goal is to make the transition as smooth as possible.