Ultraconserved elements are DNA sequences, hundreds of base pairs long, that are 100-percent identical in mice, rats and humans. Their perfect conservation for over 80 million years was thought due to evolutionary pressure, such that if even one nucleotide changes, the organism would die. But in a new study by researchers at Lawrence Berkeley National Laboratory and the Department of Energy's Joint Genome Institute, knockout mice with deleted ultraconserved elements showed virtually no ill effects.